Betaloc Zok Adverse Reactions

Adverse reactions occur in approximately 10% of the patients and they are usually dose-related. Adverse reactions, related to metoprolol are presented as follows according to organ class and frequency. The frequencies are defined as following: very common (≥1/10), common (≥1/100, <1/10), less common (≥1/1000, <1/100), rare (≥1/10,000, <1/1000), very rare (<1/10,000) and frequency unknown (cannot be calculated from available data).
Blood and lymphatic system: Rare: Thrombocytopenia.
Psychiatric disorders: Less common: Depression, nightmares, sleeping disturbance.
Rare: Memory impairment, confusion, hallucinations, nervousness, anxiety.
Frequency unknown: Impaired concentration ability.
Central and peripheral nervous system: Very common: Fatigue.
Common: Dizziness, headache.
Less common: Paraesthesiae.
Rare: Taste disturbances.
Frequency unknown: Muscular cramps.
Eyes: Rare: Visual disturbances, dry and/or irritated eyes.
Unknown frequency: Conjunctivitis-like symptoms.
Ears and balance organ: Rare: Tinnitus.
Heart: Common: Peripheral coldness in extremities, bradycardia, palpitations.
Less common: Transient aggravation of heart failure, cardiogenic shock in patients with acute myocardial infarction.
Rare: Prolonged AV-conduction time, cardiac arrhythmias.
Frequency unknown: Gangrene in patients with severe peripheral vascular disorders.
Respiratory: Common: Shortness of breath when physically active.
Less common: Bronchospasm in patients with bronchial asthma or asthmatic problems.
Frequency unknown: Rhinitis.
Gastrointestinal: Common: Abdominal pain, nausea, vomiting, diarrhoea, constipation.
Frequency unknown: Dry mouth.
Liver and biliary tracts: Rare: Elevated transaminases.
Frequency unknown: Hepatitis.
Skin and subcutaneous tissue: Less common: Hypersensitivity reactions in the skin.
Rare: Aggravated psoriasis, photosensitivity reactions, hyperhidrosis, hair loss.
Musculoskeletal system and connective tissue: Frequency unknown: Arthralgia.
Reproductive organs and mammary glands: Rare: Reversible libido dysfunction.
General: Less common: Chest pain, oedema, weight gain.